[HTML][HTML] Preformed and de novo donor specific antibodies in visceral transplantation: long-term outcome with special reference to the liver
KM Abu-Elmagd, G Wu, G Costa, J Lunz… - American Journal of …, 2012 - Elsevier
Despite improvement in early outcome, rejection particularly chronic allograft enteropathy
continues to be a major barrier to long-term visceral engraftment. The potential role of donor
specific antibodies (DSA) was examined in 194 primary adult recipients. All underwent
complement-dependent lymphocytotoxic crossmatch (CDC-XM) with pre-and posttransplant
solid phase HLA–DSA assay in 156 (80%). Grafts were ABO-identical with random HLA-
match. Liver was included in 71 (37%) allografts. Immunosuppression was tacrolimus-based …
continues to be a major barrier to long-term visceral engraftment. The potential role of donor
specific antibodies (DSA) was examined in 194 primary adult recipients. All underwent
complement-dependent lymphocytotoxic crossmatch (CDC-XM) with pre-and posttransplant
solid phase HLA–DSA assay in 156 (80%). Grafts were ABO-identical with random HLA-
match. Liver was included in 71 (37%) allografts. Immunosuppression was tacrolimus-based …