[HTML][HTML] Role of sphingosine-1-phosphate in transplant vasculopathy evoked by anti-HLA antibody
M Trayssac, S Galvani, N Augé, R Sabbadini… - American Journal of …, 2015 - Elsevier
Transplant vasculopathy (TV) represents the main cause of late graft failure and limits the
long-term success of organ transplantation. Cellular and humoral immune responses
contribute to the pathogenesis of the concentric and diffuse intimal hyperplasia of arteries of
the grafted organ. We recently reported that the mitogenic signaling, evoked in human
vascular smooth muscle cells (hmSMC) by the anti-HLA class I monoclonal antibody W6/32,
implicates neutral sphingomyelinase-2, suggesting a role for sphingolipids in intimal …
long-term success of organ transplantation. Cellular and humoral immune responses
contribute to the pathogenesis of the concentric and diffuse intimal hyperplasia of arteries of
the grafted organ. We recently reported that the mitogenic signaling, evoked in human
vascular smooth muscle cells (hmSMC) by the anti-HLA class I monoclonal antibody W6/32,
implicates neutral sphingomyelinase-2, suggesting a role for sphingolipids in intimal …