Pathologic classification of antibody-mediated rejection correlates with donor-specific antibodies and endothelial cell activation
Background Humoral immune responses during heart transplantation may result in antibody-
mediated rejection (AMR), which is now taken into account on endomyocardial biopsy
(EMB) specimens and ranked according to the pathologic AMR (pAMR) grades of the
International Society for Heart and Lung Transplantation classification. This classification
might benefit from new immunohistological markers and validation by others biomarkers,
namely donor-specific antibodies (DSA). Methods From the 293 protocol EMBs performed in …
mediated rejection (AMR), which is now taken into account on endomyocardial biopsy
(EMB) specimens and ranked according to the pathologic AMR (pAMR) grades of the
International Society for Heart and Lung Transplantation classification. This classification
might benefit from new immunohistological markers and validation by others biomarkers,
namely donor-specific antibodies (DSA). Methods From the 293 protocol EMBs performed in …