Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

SI Grivennikov, M Karin - Cytokine & growth factor reviews, 2010 - Elsevier
Transcriptional factors of the NF-κB family and STAT3 are ubiquitously expressed and
control numerous physiological processes including development, differentiation, immunity,
metabolism and cancer. Both NF-κB and STAT3 are rapidly activated in response to various
stimuli including stresses and cytokines, although they are regulated by entirely different
signaling mechanisms. Once activated, NF-κB and STAT3 control the expression of anti-
apoptotic, pro-proliferative and immune response genes. Some of these genes overlap and …