Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat
SO Syrjälä, MAI Keränen, R Tuuminen… - The Journal of Heart and …, 2010 - Elsevier
BACKGROUND: Preservation injury decreases patient survival and promotes the
development of cardiac allograft vasculopathy. We investigated the sequential effects of
hypothermic preservation on ischemia-reperfusion injury (IRI), subsequent innate immune
activation, and adaptive immune response in rat cardiac allografts. METHODS: Allografts
were transplanted from fully major histocompatibility complex-mismatched Dark Agouti to
Wistar Furth rats without pre-operative hypothermia or after 4 hours of hypothermic …
development of cardiac allograft vasculopathy. We investigated the sequential effects of
hypothermic preservation on ischemia-reperfusion injury (IRI), subsequent innate immune
activation, and adaptive immune response in rat cardiac allografts. METHODS: Allografts
were transplanted from fully major histocompatibility complex-mismatched Dark Agouti to
Wistar Furth rats without pre-operative hypothermia or after 4 hours of hypothermic …