Myocardial heat shock protein 60 expression is upregulated following acute cardiac rejection
S Sarri, SM Shaw, MA Gieschen-Krische, L Archer… - Transplant …, 2009 - Elsevier
Background Heat shock proteins (HSPs) are endogenous adjuvants which are upregulated
following cellular injury. HSP60 may be upregulated in response to myocardial injury,
inducing activation via TLR ligation on monocytes, dendritic cells and T cells. On these
grounds, this study was designed to assess HSP60 expression during the rejection process
following cardiac transplantation. Methods Intracellular and cell surface endomyocardial
concentration of HSP60 was quantified longitudinally in a cohort of heart transplant …
following cellular injury. HSP60 may be upregulated in response to myocardial injury,
inducing activation via TLR ligation on monocytes, dendritic cells and T cells. On these
grounds, this study was designed to assess HSP60 expression during the rejection process
following cardiac transplantation. Methods Intracellular and cell surface endomyocardial
concentration of HSP60 was quantified longitudinally in a cohort of heart transplant …