CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection
O Yoshida, L Dou, S Kimura, S Yokota, K Isse… - Transplant …, 2015 - Elsevier
Adenosine triphosphate (ATP), an essential metabolic energy source, is released following
cell apoptosis or necrosis. It acts as a damage-associated molecule pattern to stimulate
innate immune cells. The ectonucleotidase CD39 regulates immune activation by hydrolysis
of extracellular ATP. We have shown previously that CD39 expression by donor livers helps
protect syngeneic grafts with extended (24 h) cold preservation time from ischemia
reperfusion injury. Given its immune regulatory properties, we hypothesized that CD39 …
cell apoptosis or necrosis. It acts as a damage-associated molecule pattern to stimulate
innate immune cells. The ectonucleotidase CD39 regulates immune activation by hydrolysis
of extracellular ATP. We have shown previously that CD39 expression by donor livers helps
protect syngeneic grafts with extended (24 h) cold preservation time from ischemia
reperfusion injury. Given its immune regulatory properties, we hypothesized that CD39 …