[HTML][HTML] Receptor for advanced glycation end products (RAGE) on iNKT cells mediates lung ischemia–reperfusion injury
AK Sharma, DJ LaPar, ML Stone, Y Zhao… - American Journal of …, 2013 - Elsevier
Activation of invariant natural killer T (iNKT) cells and signaling through receptor for
advanced glycation end products (RAGE) are known to independently mediate lung
ischemia–reperfusion (IR) injury. This study tests the hypothesis that activation of RAGE
specifically on iNKT cells via alveolar macrophage-produced high mobility group box 1
(HMGB1) is critical for the initiation of lung IR injury. A murine in vivo hilar clamp model was
utilized, which demonstrated that RAGE−/− mice were significantly protected from IR injury …
advanced glycation end products (RAGE) are known to independently mediate lung
ischemia–reperfusion (IR) injury. This study tests the hypothesis that activation of RAGE
specifically on iNKT cells via alveolar macrophage-produced high mobility group box 1
(HMGB1) is critical for the initiation of lung IR injury. A murine in vivo hilar clamp model was
utilized, which demonstrated that RAGE−/− mice were significantly protected from IR injury …