[HTML][HTML] Prevention of allograft rejection by use of regulatory T cells with an MHC-specific chimeric antigen receptor
F Noyan, K Zimmermann, M Hardtke-Wolenski… - American Journal of …, 2017 - Elsevier
CD4+ CD25 high FOXP3+ regulatory T cells (Tregs) are involved in graft-specific tolerance
after solid organ transplantation. However, adoptive transfer of polyspecific Tregs alone is
insufficient to prevent graft rejection even in rodent models, indicating that graft-specific
Tregs are required. We developed a highly specific chimeric antigen receptor that
recognizes the HLA molecule A* 02 (referred to as A2-CAR). Transduction into natural
regulatory T cells (nTregs) changes the specificity of the nTregs without alteration of their …
after solid organ transplantation. However, adoptive transfer of polyspecific Tregs alone is
insufficient to prevent graft rejection even in rodent models, indicating that graft-specific
Tregs are required. We developed a highly specific chimeric antigen receptor that
recognizes the HLA molecule A* 02 (referred to as A2-CAR). Transduction into natural
regulatory T cells (nTregs) changes the specificity of the nTregs without alteration of their …