[HTML][HTML] Expression of a chimeric antigen receptor specific for donor HLA class I enhances the potency of human regulatory T cells in preventing human skin transplant …
DA Boardman, C Philippeos, GO Fruhwirth… - American Journal of …, 2017 - Elsevier
Regulatory T cell (Treg) therapy using recipient-derived Tregs expanded ex vivo is currently
being investigated clinically by us and others as a means of reducing allograft rejection
following organ transplantation. Data from animal models has demonstrated that adoptive
transfer of allospecific Tregs offers greater protection from graft rejection compared to
polyclonal Tregs. Chimeric antigen receptors (CAR) are clinically translatable synthetic
fusion proteins that can redirect the specificity of T cells toward designated antigens. We …
being investigated clinically by us and others as a means of reducing allograft rejection
following organ transplantation. Data from animal models has demonstrated that adoptive
transfer of allospecific Tregs offers greater protection from graft rejection compared to
polyclonal Tregs. Chimeric antigen receptors (CAR) are clinically translatable synthetic
fusion proteins that can redirect the specificity of T cells toward designated antigens. We …