[HTML][HTML] Ex vivo inhibition of NF-κB signaling in alloreactive T-cells prevents graft-versus-host disease
MJ O'shaughnessy, C Vogtenhuber, K Sun… - American Journal of …, 2009 - Elsevier
The ex vivo induction of alloantigen-specific hyporesponsiveness by costimulatory pathway
blockade or exposure to immunoregulatory cytokines has been shown to inhibit proliferation,
IL-2 production, and the graft-versus-host disease (GVHD) capacity of adoptively transferred
T-cells. We hypothesized that inhibition of the intracellular NF-κB pathway in alloreactive T-
cells, which is critical for T-cell activation events including IL-2 transcription, could lead to
alloantigen hyporesponsiveness and loss of GVHD capacity. We demonstrate that treatment …
blockade or exposure to immunoregulatory cytokines has been shown to inhibit proliferation,
IL-2 production, and the graft-versus-host disease (GVHD) capacity of adoptively transferred
T-cells. We hypothesized that inhibition of the intracellular NF-κB pathway in alloreactive T-
cells, which is critical for T-cell activation events including IL-2 transcription, could lead to
alloantigen hyporesponsiveness and loss of GVHD capacity. We demonstrate that treatment …