In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia
contributes to the development of a pro-thrombotic state. In this context, it has been
demonstrated that advanced glycation end products (AGEs) significantly increases platelet
activation and receptor for AGEs (RAGE) expression at the platelet surface membrane. In
addition to AGEs, other ligands (S100, HMGB1 and amyloid β, among others) of RAGE have
raised particular attention in platelet activation. Therefore, in this article we describe platelet …