Progress and obstacles towards generating hematopoietic stem cells from pluripotent stem cells

J Lee, B Dykstra, R Sackstein… - Current opinion in …, 2015 - journals.lww.com
J Lee, B Dykstra, R Sackstein, DJ Rossi
Current opinion in hematology, 2015journals.lww.com
Despite considerable progress in defining the molecular events driving derivation of
hematopoietic progenitor cells from PSCs, the generation of robust transplantable HSCs
from PSCs remains elusive. We propose that this goal can be facilitated by better
understanding of the regulatory pathways governing HSC identity, development of HSC
supportive conditions, and examining the marrow homing properties of PSC-derived HSCs.
Summary
Despite considerable progress in defining the molecular events driving derivation of hematopoietic progenitor cells from PSCs, the generation of robust transplantable HSCs from PSCs remains elusive. We propose that this goal can be facilitated by better understanding of the regulatory pathways governing HSC identity, development of HSC supportive conditions, and examining the marrow homing properties of PSC-derived HSCs.
Lippincott Williams & Wilkins