Fucosylation with fucosyltransferase VI or fucosyltransferase VII improves cord blood engraftment
SN Robinson, MW Thomas, PJ Simmons, J Lu, H Yang… - Cytotherapy, 2014 - Elsevier
Background aims Advantages associated with the use of cord blood (CB) transplantation
include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-
versus-host disease compared with bone marrow or mobilized peripheral blood. However,
poor engraftment remains a major obstacle. We and others have found that ex vivo
fucosylation can enhance engraftment in murine models, and now ex vivo treatment of CB
with fucosyltransferase (FT) VI before transplantation is under clinical evaluation …
include the availability of cryopreserved units, ethnic diversity and lower incidence of graft-
versus-host disease compared with bone marrow or mobilized peripheral blood. However,
poor engraftment remains a major obstacle. We and others have found that ex vivo
fucosylation can enhance engraftment in murine models, and now ex vivo treatment of CB
with fucosyltransferase (FT) VI before transplantation is under clinical evaluation …