The cellular delivery of antisense oligonucleotides and ribozymes
MD Hughes, M Hussain, Q Nawaz, P Sayyed… - Drug discovery today, 2001 - Elsevier
MD Hughes, M Hussain, Q Nawaz, P Sayyed, S Akhtar
Drug discovery today, 2001•ElsevierThe design and development of antisense oligonucleotides and ribozymes for the treatment
of diseases arising from genetic abnormalities has become a real possibility over the past
few years. Improvements in oligonucleotide chemistry have led to the synthesis of nucleic
acids that are relatively stable in the biological milieu. However, advances in cellular
targeting and intracellular delivery will probably lead to more widespread clinical
applications. This review looks at recent advances in the in vitro and in vivo delivery of …
of diseases arising from genetic abnormalities has become a real possibility over the past
few years. Improvements in oligonucleotide chemistry have led to the synthesis of nucleic
acids that are relatively stable in the biological milieu. However, advances in cellular
targeting and intracellular delivery will probably lead to more widespread clinical
applications. This review looks at recent advances in the in vitro and in vivo delivery of …
The design and development of antisense oligonucleotides and ribozymes for the treatment of diseases arising from genetic abnormalities has become a real possibility over the past few years. Improvements in oligonucleotide chemistry have led to the synthesis of nucleic acids that are relatively stable in the biological milieu. However, advances in cellular targeting and intracellular delivery will probably lead to more widespread clinical applications. This review looks at recent advances in the in vitro and in vivo delivery of antisense oligodeoxynucleotides and ribozymes.
Elsevier