[HTML][HTML] Dendritic epidermal T cells: lessons from mice for humans

PR Bergstresser, PD Cruz Jr, A Takashima - Journal of investigative …, 1993 - Elsevier
PR Bergstresser, PD Cruz Jr, A Takashima
Journal of investigative dermatology, 1993Elsevier
Dendritic epidermal T cells (DETC) in mice form part of a primitive system of epithelial-
resident T cells characterized by the expression of gd T-cell receptors (TCR). Critical
attributes that characterize DETC include their highly restricted T-cell receptor gene
utilization, proliferation and maturation within epidermis, a capacity to kill relevant skin-
derived tumor targets, and the ability to modulate immune responses that are initiated and
expressed in skin. Contemporary knowledge suggests that DETC and the related skin …
Dendritic epidermal T cells (DETC) in mice form part of a primitive system of epithelial-resident T cells characterized by the expression of gd T-cell receptors (TCR). Critical attributes that characterize DETC include their highly restricted T-cell receptor gene utilization, proliferation and maturation within epidermis, a capacity to kill relevant skin-derived tumor targets, and the ability to modulate immune responses that are initiated and expressed in skin. Contemporary knowledge suggests that DETC and the related skin-directed gd T cells found in humans play important roles in maintaining the immunologic integrity of skin.
Elsevier