This review article summarizes the recent advances in pathogenic mechanisms and novel
therapeutic strategies for osteomyelitis, covering both periprosthetic joint infections and
fracture-associated bone infections. A better understanding of the pathophysiology including
the mechanisms for biofilm formation has led to new therapeutic strategies for this
devastating disease. Research on novel local delivery materials with appropriate
mechanical properties, lower exothermicity, controlled release of antibiotics, and absorbable …