Formation of the inflammasome during cardiac allograft rejection
KB Shah, AG Mauro, M Flattery… - International …, 2015 - internationaljournalofcardiology.com
While heart transplantation (HTx) is the definitive therapy for end stage heart failure, an
immune response toward non-self inevitably occurs in all recipients and requires
preventative treatment with immunosuppressive therapies. Despite therapy, approximately 1
in 15 patients will experience an acute rejection threatening the function of the transplanted
heart [1]. Acute rejection refers to injury and death of the cardiomyocytes secondary to an
immune (cell or antibody mediated) response. The severity of injury depends on the intensity …
immune response toward non-self inevitably occurs in all recipients and requires
preventative treatment with immunosuppressive therapies. Despite therapy, approximately 1
in 15 patients will experience an acute rejection threatening the function of the transplanted
heart [1]. Acute rejection refers to injury and death of the cardiomyocytes secondary to an
immune (cell or antibody mediated) response. The severity of injury depends on the intensity …