NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese
MS Tan, JT Yu, T Jiang, XC Zhu, HF Wang… - Journal of …, 2013 - Elsevier
The innate immunity and inflammatory response plays an important role in AD
pathogenesis. Recently, a wealth of information linking the activation of NLRP3
inflammasome to Alzheimer's disease (AD) pathogenesis has emerged. Considering the
pivotal role of NLRP3 in the inflammatory process and in AD, we hypothesized that
variations in NLRP3 gene may also affect susceptibility to AD. Three selected functional
single-nucleotide polymorphisms (SNPs) in NLRP3 gene (rs2027432, rs10754558 …
pathogenesis. Recently, a wealth of information linking the activation of NLRP3
inflammasome to Alzheimer's disease (AD) pathogenesis has emerged. Considering the
pivotal role of NLRP3 in the inflammatory process and in AD, we hypothesized that
variations in NLRP3 gene may also affect susceptibility to AD. Three selected functional
single-nucleotide polymorphisms (SNPs) in NLRP3 gene (rs2027432, rs10754558 …