[HTML][HTML] Activation of p53 by the MDM2 inhibitor RG7112 impairs thrombopoiesis
C Iancu-Rubin, G Mosoyan, K Glenn, RE Gordon… - Experimental …, 2014 - Elsevier
The tumor suppressor p53 is thought to play a role in megakaryocyte (MK) development. To
assess the influence of the p53 regulatory pathway further, we studied the effect of RG7112,
a small molecule MDM2 antagonist that activates p53 by preventing its interaction with
MDM2, on normal megakaryocytopoiesis and platelet production. This drug has been
previously been evaluated in clinical trials of cancer patients where thrombocytopenia was
one of the major dose-limiting toxicities. In this study, we demonstrated that administration of …
assess the influence of the p53 regulatory pathway further, we studied the effect of RG7112,
a small molecule MDM2 antagonist that activates p53 by preventing its interaction with
MDM2, on normal megakaryocytopoiesis and platelet production. This drug has been
previously been evaluated in clinical trials of cancer patients where thrombocytopenia was
one of the major dose-limiting toxicities. In this study, we demonstrated that administration of …