Platelet-derived growth factor (PDGF) isoforms play a major role in stimulating the
replication, survival, and migration of myofibroblasts during the pathogenesis of fibrotic
diseases. During fibrogenesis, PDGF is secreted by a variety of cell types as a response to
injury, and many pro-inflammatory cytokines mediate their mitogenic effects via the autocrine
release of PDGF. PDGF action is determined by the relative expression of PDGF α-receptors
(PDGFRα) and β-receptors (PDGFRβ) on the surface of myofibroblasts. These receptors are …