Isoflurane blocks synaptic plasticity in the mouse hippocampus
W Simon, G Hapfelmeier, E Kochs… - The Journal of the …, 2001 - pubs.asahq.org
Background The volatile anesthetic isoflurane depresses glutamatergic transmission. In this
study, the authors investigated the effects of isoflurane on the induction of long-term
potentiation (LTP) and long-term depression (LTD) in slices from the juvenile and adult
mouse hippocampus. Both forms of synaptic plasticity involve the activation of glutamate
receptors. Methods Field excitatory postsynaptic potentials and excitatory postsynaptic
currents from neurons in the CA1 area were evoked by stimulation of the Schaffer collateral …
study, the authors investigated the effects of isoflurane on the induction of long-term
potentiation (LTP) and long-term depression (LTD) in slices from the juvenile and adult
mouse hippocampus. Both forms of synaptic plasticity involve the activation of glutamate
receptors. Methods Field excitatory postsynaptic potentials and excitatory postsynaptic
currents from neurons in the CA1 area were evoked by stimulation of the Schaffer collateral …