SIRT1—a metabolic sensor that controls blood vessel growth
V Guarani, M Potente - Current Opinion in Pharmacology, 2010 - Elsevier
Blood vessels deliver nutrients and oxygen to cells and tissues in the body. When blood
supply is insufficient new vessels form to meet the metabolic tissue requirements. Several
studies have examined the cellular and molecular principles of blood vessel formation, yet
little is known about how vessels sense and integrate environmental signals originating from
nutrient-and oxygen-deprived tissues to achieve functional vascular patterning. The NAD+-
dependent deacetylase SIRT1 mediates adaptation to environmental stresses by adjusting …
supply is insufficient new vessels form to meet the metabolic tissue requirements. Several
studies have examined the cellular and molecular principles of blood vessel formation, yet
little is known about how vessels sense and integrate environmental signals originating from
nutrient-and oxygen-deprived tissues to achieve functional vascular patterning. The NAD+-
dependent deacetylase SIRT1 mediates adaptation to environmental stresses by adjusting …