[HTML][HTML] Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis
J Lu, KI Izvolsky, J Qian, WV Cardoso - Journal of Biological Chemistry, 2005 - ASBMB
Genetic studies implicate Fgf10-Fgfr2 signaling as a critical regulator of bud morphogenesis
in the embryo. However, little is known about the transcriptional targets of Fgf10 during this
process. Here we identified global changes in gene expression in lung epithelial explants
undergoing FGF10-mediated budding in the absence of other growth factors and
mesenchyme. Targets were confirmed by their localization at sites where endogenous Fgf10
signaling is active in embryonic lungs and by demonstrating their induction in intact lungs in …
in the embryo. However, little is known about the transcriptional targets of Fgf10 during this
process. Here we identified global changes in gene expression in lung epithelial explants
undergoing FGF10-mediated budding in the absence of other growth factors and
mesenchyme. Targets were confirmed by their localization at sites where endogenous Fgf10
signaling is active in embryonic lungs and by demonstrating their induction in intact lungs in …