Myelodysplastic syndromes (MDS) are a constellation of different diseases sharing anemia
in the great majority of cases, and this cytopenia defines these pathologies and their most
dramatic clinical manifestations. Anemia in MDS is due to ineffective erythropoiesis, with a
high degree of apoptosis of marrow erythroid progenitors. These progenitors show
distinctive dysplastic features that consent diagnosis, and are recognizable and
differentiated, although not easily, from other morphologic alterations present in other types …