A functional magnetic resonance imaging study of tic suppression in Tourette syndrome

BS Peterson, P Skudlarski, AW Anderson… - Archives of general …, 1998 - jamanetwork.com
Background: The inability to inhibit unwanted behaviors and impulses produces functional
debility in a broad range of neuropsychiatric disorders. A potentially important model of
impulse control is volitional tic suppression in Tourette syndrome. Methods Tic suppression
was studied in 22 adult subjects with Tourette syndrome by using functional magnetic
resonance imaging. Images acquired during periods of voluntary tic suppression were
compared with images acquired when subjects allowed the spontaneous expression of their …