Patterns of fetoplacental angiogenesis vary during gestation and in association with certain
pregnancy pathologies. In a set of three linked reviews, we provide a survey of current
knowledge about the molecular regulation, cellular players, qualitative and quantitative
morphological features of the vascularization of human placental villi. Here, an account is
given of the role played by hypoxia-inducible factor in mediating the effects of oxygen on
production of growth factor ligands and receptors which regulate angiogenesis and vessel …