Screening for vaginal shedding of cytomegalovirus in healthy pregnant women using real‐time PCR: Correlation of CMV in the vagina and adverse outcome of …
K Tanaka, H Yamada, M Minami… - Journal of medical …, 2006 - Wiley Online Library
K Tanaka, H Yamada, M Minami, S Kataoka, K Numazaki, H Minakami, H Tsutsumi
Journal of medical virology, 2006•Wiley Online LibraryThe impact of cytomegalovirus (CMV) infection of the genital tract during pregnancy on
adverse pregnancy outcomes is not understood fully. A real‐time PCR assay was used to
determine vaginal shedding of CMV in 993 healthy pregnant Japanese women and the
results were compared with the outcome of pregnancy. CMV DNA was detected in 76 (7.7%)
of the women. The outcome of pregnancy could be determined finally in 848 women, of
whom 60 (7.1%) were CMV positive. The carriers of CMV had an increased miscarriage rate …
adverse pregnancy outcomes is not understood fully. A real‐time PCR assay was used to
determine vaginal shedding of CMV in 993 healthy pregnant Japanese women and the
results were compared with the outcome of pregnancy. CMV DNA was detected in 76 (7.7%)
of the women. The outcome of pregnancy could be determined finally in 848 women, of
whom 60 (7.1%) were CMV positive. The carriers of CMV had an increased miscarriage rate …
Abstract
The impact of cytomegalovirus (CMV) infection of the genital tract during pregnancy on adverse pregnancy outcomes is not understood fully. A real‐time PCR assay was used to determine vaginal shedding of CMV in 993 healthy pregnant Japanese women and the results were compared with the outcome of pregnancy. CMV DNA was detected in 76 (7.7%) of the women. The outcome of pregnancy could be determined finally in 848 women, of whom 60 (7.1%) were CMV positive. The carriers of CMV had an increased miscarriage rate (RR 6.96, 95% CI 2.04–23.84, P < 0.01). These findings suggest that latent genital tract CMV infection predisposes to adverse pregnancy outcomes. J. Med. Virol. 78:757–759, 2006. © 2006 Wiley‐Liss, Inc.
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