[HTML][HTML] Regulation and function of mTOR signalling in T cell fate decisions

H Chi - Nature reviews immunology, 2012 - nature.com
H Chi
Nature reviews immunology, 2012nature.com
The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell
growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR
signalling to integrate immune signals and metabolic cues for their proper maintenance and
activation. Under steady-state conditions, mTOR is actively controlled by multiple inhibitory
mechanisms, and this enforces normal T cell homeostasis. Antigen recognition by naive
CD4+ and CD8+ T cells triggers mTOR activation, which in turn programmes the …
Abstract
The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR signalling to integrate immune signals and metabolic cues for their proper maintenance and activation. Under steady-state conditions, mTOR is actively controlled by multiple inhibitory mechanisms, and this enforces normal T cell homeostasis. Antigen recognition by naive CD4+ and CD8+ T cells triggers mTOR activation, which in turn programmes the differentiation of these cells into functionally distinct lineages. This Review focuses on the signalling mechanisms of mTOR in T cell homeostatic and functional fates, and discusses the therapeutic implications of targeting mTOR in T cells.
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