[HTML][HTML] Estrogen receptor-β-selective ligands alleviate high-fat diet-and ovariectomy-induced obesity in mice
M Yepuru, J Eswaraka, JD Kearbey, CM Barrett… - Journal of Biological …, 2010 - ASBMB
Obesity is an epidemic problem affecting millions of people in the Western hemisphere and
costs the United States economy more than $200 billion annually. Currently, there are no
effective treatments to combat obesity. Recent studies have implicated the constitutive
activity of estrogen receptor (ER) β as an important regulator of metabolic diseases.
However, the potential of ER-β-selective ligands to offset obesity is not clear. We evaluated
the pharmacological effect of ER-β-selective ligands (β-LGNDs) in animal models of high-fat …
costs the United States economy more than $200 billion annually. Currently, there are no
effective treatments to combat obesity. Recent studies have implicated the constitutive
activity of estrogen receptor (ER) β as an important regulator of metabolic diseases.
However, the potential of ER-β-selective ligands to offset obesity is not clear. We evaluated
the pharmacological effect of ER-β-selective ligands (β-LGNDs) in animal models of high-fat …