Blockade of PDGFR-β activation eliminates morphine analgesic tolerance
Y Wang, K Barker, S Shi, M Diaz, B Mo, HB Gutstein - Nature medicine, 2012 - nature.com
Y Wang, K Barker, S Shi, M Diaz, B Mo, HB Gutstein
Nature medicine, 2012•nature.comFor centuries, opioid drugs have been the mainstay of chronic pain treatment. However, over
time analgesic tolerance develops, leaving few treatment options. Here we show that
platelet-derived growth factor receptor-β (PDGFR-β)-mediated signaling plays a key role in
morphine tolerance. PDGFR-β inhibition selectively eliminates morphine tolerance in rats.
PDGFR-β inhibitors are widely used and well tolerated, suggesting that clinical translation of
our findings could reduce the suffering endured by individuals with intractable pain.
time analgesic tolerance develops, leaving few treatment options. Here we show that
platelet-derived growth factor receptor-β (PDGFR-β)-mediated signaling plays a key role in
morphine tolerance. PDGFR-β inhibition selectively eliminates morphine tolerance in rats.
PDGFR-β inhibitors are widely used and well tolerated, suggesting that clinical translation of
our findings could reduce the suffering endured by individuals with intractable pain.
Abstract
For centuries, opioid drugs have been the mainstay of chronic pain treatment. However, over time analgesic tolerance develops, leaving few treatment options. Here we show that platelet-derived growth factor receptor-β (PDGFR-β)-mediated signaling plays a key role in morphine tolerance. PDGFR-β inhibition selectively eliminates morphine tolerance in rats. PDGFR-β inhibitors are widely used and well tolerated, suggesting that clinical translation of our findings could reduce the suffering endured by individuals with intractable pain.
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