Abdominal aortic aneurysms (AAA) are characterized by pathological remodeling of the
aortic extracellular matrix (ECM). However, besides the well-characterized elastolysis and
collagenolysis little is known about changes in other ECM proteins. Previous proteomics
studies on AAA focused on cellular changes without emphasis on the ECM. In the present
study, ECM proteins and their degradation products were selectively extracted from
aneurysmal and control aortas using a solubility-based subfractionation methodology and …