[HTML][HTML] p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor α: a potential role in the cardiac metabolic stress response
PM Barger, AC Browning, AN Garner… - Journal of Biological …, 2001 - ASBMB
The expression of enzymes involved in fatty acid β-oxidation (FAO), the principal source of
energy production in the adult mammalian heart, is controlled at the transcriptional level via
the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). Evidence has
emerged that PPARα activity is activated as a component of an energy metabolic stress
response. The p38 mitogen-activated protein kinase (MAPK) pathway is activated by cellular
stressors in the heart, including ischemia, hypoxia, and hypertrophic growth stimuli. We …
energy production in the adult mammalian heart, is controlled at the transcriptional level via
the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). Evidence has
emerged that PPARα activity is activated as a component of an energy metabolic stress
response. The p38 mitogen-activated protein kinase (MAPK) pathway is activated by cellular
stressors in the heart, including ischemia, hypoxia, and hypertrophic growth stimuli. We …