[HTML][HTML] Activation of the farnesoid X receptor induces hepatic expression and secretion of fibroblast growth factor 21
HA Cyphert, X Ge, AB Kohan, LM Salati… - Journal of Biological …, 2012 - ASBMB
Background: The hormone FGF21 is a potent regulator of carbohydrate and lipid metabolism
and a promising drug for treating metabolic syndrome. Results: Farnesoid X receptor (FXR)
agonists and FGF19 induce hepatic FGF21 secretion via a transcriptional mechanism and
posttranscriptional mechanism, respectively. Conclusion: Activation of the FXR pathway
stimulates FGF21 expression and secretion. Significance: Activation of FXR is a potential
approach to enhance endogenous FGF21 production and reverse metabolic syndrome.
and a promising drug for treating metabolic syndrome. Results: Farnesoid X receptor (FXR)
agonists and FGF19 induce hepatic FGF21 secretion via a transcriptional mechanism and
posttranscriptional mechanism, respectively. Conclusion: Activation of the FXR pathway
stimulates FGF21 expression and secretion. Significance: Activation of FXR is a potential
approach to enhance endogenous FGF21 production and reverse metabolic syndrome.