[HTML][HTML] Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor

N Yamamoto, S Yamamoto, F Inagaki… - Journal of Biological …, 2001 - ASBMB
Intercellular signaling through the cell-surface receptor Notch plays important roles in a
variety of developmental processes as well as in pathogenesis of some human cancers and
genetic disorders. However, the mechanisms by which Notch signals are transduced into
cells still remain elusive. Here we investigated the signaling mechanisms for Notch in the
cell fate control of neural progenitor cells. We show that Deltex-1 (DTX1), a mammalian
homolog ofDrosophila Deltex, mediates a Notch signal to block differentiation of neural …