[HTML][HTML] Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival
DM Lapierre, N Tanabe, A Pereverzev… - Journal of biological …, 2010 - ASBMB
Lysophosphatidic acid (LPA) is a bioactive phospholipid whose functions are mediated by
multiple G protein-coupled receptors. We have shown that osteoblasts produce LPA, raising
the possibility that it mediates intercellular signaling among osteoblasts and osteoclasts.
Here we investigated the expression, signaling and function of LPA receptors in osteoclasts.
Focal application of LPA elicited transient increases in cytosolic calcium concentration ([Ca
2+] i), with 50% of osteoclasts responding at∼ 400 nm LPA. LPA-induced elevation of [Ca …
multiple G protein-coupled receptors. We have shown that osteoblasts produce LPA, raising
the possibility that it mediates intercellular signaling among osteoblasts and osteoclasts.
Here we investigated the expression, signaling and function of LPA receptors in osteoclasts.
Focal application of LPA elicited transient increases in cytosolic calcium concentration ([Ca
2+] i), with 50% of osteoclasts responding at∼ 400 nm LPA. LPA-induced elevation of [Ca …