β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target
AP Lam, CJ Gottardi - Current opinion in rheumatology, 2011 - journals.lww.com
AP Lam, CJ Gottardi
Current opinion in rheumatology, 2011•journals.lww.comWnt/β-catenin signaling appears important in normal wound healing and its sustained
activation is associated with fibrogenesis. The mechanism by which Wnt/β-catenin signaling
may modify the response to injury is cell-type and context-dependent. Better understanding
of this signaling pathway may provide a promising new therapeutic approach for human
fibrotic diseases.
activation is associated with fibrogenesis. The mechanism by which Wnt/β-catenin signaling
may modify the response to injury is cell-type and context-dependent. Better understanding
of this signaling pathway may provide a promising new therapeutic approach for human
fibrotic diseases.
Summary
Wnt/β-catenin signaling appears important in normal wound healing and its sustained activation is associated with fibrogenesis. The mechanism by which Wnt/β-catenin signaling may modify the response to injury is cell-type and context-dependent. Better understanding of this signaling pathway may provide a promising new therapeutic approach for human fibrotic diseases.
Lippincott Williams & Wilkins