GATA-3 expression as a predictor of hormone response in breast cancer
P Parikh, JP Palazzo, LJ Rose… - Journal of the …, 2005 - journals.lww.com
Background Expression of estrogen receptor-α (ERα) as determined by
immunohistochemistry of tumor tissue is currently the most clinically useful test to predict
hormone responsiveness of breast cancer. Thirty percent of ERα-positive breast cancers do
not respond to hormonal therapy. GATA-3 is a transcription factor that is expressed in
association with ERα and there is evidence that GATA factors influence response to
estrogen. In this pilot study, we investigated whether GATA-3 expression is associated with …
immunohistochemistry of tumor tissue is currently the most clinically useful test to predict
hormone responsiveness of breast cancer. Thirty percent of ERα-positive breast cancers do
not respond to hormonal therapy. GATA-3 is a transcription factor that is expressed in
association with ERα and there is evidence that GATA factors influence response to
estrogen. In this pilot study, we investigated whether GATA-3 expression is associated with …