[HTML][HTML] Fenofibrate decreases insulin clearance and insulin secretion to maintain insulin sensitivity
SK Ramakrishnan, L Russo, SS Ghanem… - Journal of Biological …, 2016 - ASBMB
High fat diet reduces the expression of CEACAM1 (carcinoembryonic antigen-related cell
adhesion molecule 1), a transmembrane glycoprotein that promotes insulin clearance and
down-regulates fatty acid synthase activity in the liver upon its phosphorylation by the insulin
receptor. Because peroxisome proliferator-activated receptor α (PPARα) transcriptionally
suppresses CEACAM1 expression, we herein examined whether high fat down-regulates
CEACAM1 expression in a PPARα-dependent mechanism. By activating PPARα, the lipid …
adhesion molecule 1), a transmembrane glycoprotein that promotes insulin clearance and
down-regulates fatty acid synthase activity in the liver upon its phosphorylation by the insulin
receptor. Because peroxisome proliferator-activated receptor α (PPARα) transcriptionally
suppresses CEACAM1 expression, we herein examined whether high fat down-regulates
CEACAM1 expression in a PPARα-dependent mechanism. By activating PPARα, the lipid …