Peroxisome proliferator-activated receptor delta (PPARδ) is involved in regulation of energy
homeostasis. Activation of PPARδ markedly increases fecal neutral sterol secretion, the last
step in reverse cholesterol transport. This phenomenon can neither be explained by
increased hepatobiliary cholesterol secretion, nor by reduced cholesterol absorption. To test
the hypothesis that PPARδ activation leads to stimulation of transintestinal cholesterol efflux
(TICE), we quantified it by intestine perfusions in FVB mice treated with PPARδ agonist …