Fenofibrate lowers atypical sphingolipids in plasma of dyslipidemic patients: A novel approach for treating diabetic neuropathy?
Background The condensation of palmitoyl-CoA and L-Serine is the first step in the de novo
formation of sphingolipids and catalyzed by the serine-palmitoyltransferase (SPT). Besides
other acyl-CoAs the SPT can also metabolize L-alanine and glycine, which forms an atypical
category of neurotoxic 1-deoxy-sphingolipids (1-deoxySL). Several mutations in SPT are
associated with pathologically increased 1-deoxySL levels, which cause the inherited
sensory neuropathy HSAN1. 1-DeoxySL levels are also elevated in individuals with the …
formation of sphingolipids and catalyzed by the serine-palmitoyltransferase (SPT). Besides
other acyl-CoAs the SPT can also metabolize L-alanine and glycine, which forms an atypical
category of neurotoxic 1-deoxy-sphingolipids (1-deoxySL). Several mutations in SPT are
associated with pathologically increased 1-deoxySL levels, which cause the inherited
sensory neuropathy HSAN1. 1-DeoxySL levels are also elevated in individuals with the …