The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice
M Pawlak, E Baugé, W Bourguet, K De Bosscher… - Hepatology, 2014 - journals.lww.com
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and strongly associated
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model
of NAFLD pathogenesis, lipid accumulation drives nonalcoholic steatohepatitis (NASH)
initiation by triggering oxidative stress, lipotoxicity, and subsequent activation of hepatic
inflammatory responses that may progress, in predisposed individuals, to fibrosis and
cirrhosis. While there is an unmet therapeutical need for NASH and fibrosis, recent …
with central obesity, dyslipidemia, and insulin resistance. According to the multiple-hit model
of NAFLD pathogenesis, lipid accumulation drives nonalcoholic steatohepatitis (NASH)
initiation by triggering oxidative stress, lipotoxicity, and subsequent activation of hepatic
inflammatory responses that may progress, in predisposed individuals, to fibrosis and
cirrhosis. While there is an unmet therapeutical need for NASH and fibrosis, recent …