[HTML][HTML] Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α*♦
JS Marino, LA Stechschulte, DE Stec… - Journal of Biological …, 2016 - ASBMB
Glucocorticoids (GCs) regulate energy supply in response to stress by increasing hepatic
gluconeogenesis during fasting. Long-term GC treatment induces hepatic steatosis and
weight gain. GC signaling is coordinated via the GC receptor (GR) GRα, as the GRβ isoform
lacks a ligand-binding domain. The roles of the GR isoforms in the regulation of lipid
accumulation is unknown. The purpose of this study was to determine whether GRβ inhibits
the actions of GCs in the liver, or enhances hepatic lipid accumulation. We show that GRβ …
gluconeogenesis during fasting. Long-term GC treatment induces hepatic steatosis and
weight gain. GC signaling is coordinated via the GC receptor (GR) GRα, as the GRβ isoform
lacks a ligand-binding domain. The roles of the GR isoforms in the regulation of lipid
accumulation is unknown. The purpose of this study was to determine whether GRβ inhibits
the actions of GCs in the liver, or enhances hepatic lipid accumulation. We show that GRβ …