[HTML][HTML] Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage

V Puri, S Konda, S Ranjit, M Aouadi, A Chawla… - Journal of Biological …, 2007 - ASBMB
Fat-specific protein (FSP) 27/Cidec is most highly expressed in white and brown adipose
tissues and increases in abundance by over 50-fold during adipogenesis. However, its
function in adipocytes has remained elusive since its discovery over 15 years ago. Here we
demonstrate that FSP27/Cidec localizes to lipid droplets in cultured adipocytes and
functions to promote lipid accumulation. Ectopically expressed FSP27-GFP surrounds lipid
droplets in 3T3-L1 adipocytes and colocalizes with the known lipid droplet protein perilipin …