Different effects of lysophosphatidic acid on L-type calcium current in neonatal rat ventricular myocytes with and without H2O2 treatment
R Sun, D Zhang, J Zhang, Q Feng, Y Zhang… - Prostaglandins & Other …, 2015 - Elsevier
L-type calcium current (I Ca-L) alterations are implicated in various cardiac diseases, and
the lysophosphatidic acid (LPA) level increases in several ischemic heart diseases. We
investigated the effects of LPA on I Ca-L in normal and H 2 O 2-treated neonatal rat
ventricular myocytes. LPA treatment (24 h) increased the action potential duration (APD) and
I Ca-L in normal ventricular myocytes, but it decreased these parameters in H 2 O 2-treated
myocytes. LPA increased the single-channel open probability of L-type calcium channels in …
the lysophosphatidic acid (LPA) level increases in several ischemic heart diseases. We
investigated the effects of LPA on I Ca-L in normal and H 2 O 2-treated neonatal rat
ventricular myocytes. LPA treatment (24 h) increased the action potential duration (APD) and
I Ca-L in normal ventricular myocytes, but it decreased these parameters in H 2 O 2-treated
myocytes. LPA increased the single-channel open probability of L-type calcium channels in …