[HTML][HTML] Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis
MJ Grybko, JP Bartnik, GA Wurth… - Journal of Biological …, 2007 - ASBMB
We have tested the idea that calcineurin, a calcium-dependent phosphatase that is critical
for activating cytokine gene expression in helper T cells, plays a role in lytic granule
exocytosis in cytotoxic T lymphocytes (CTLs). We used TALL-104 human leukemic CTLs as
a model. Our results confirm an earlier report (Dutz, JP, Fruman, DA, Burakoff, SJ, and
Bierer, BE (1993) J. Immunol. 150, 2591–2598) that immunosuppressive drugs inhibit
exocytosis in CTLs stimulated either via the T cell receptor (TCR) or via TCR-independent …
for activating cytokine gene expression in helper T cells, plays a role in lytic granule
exocytosis in cytotoxic T lymphocytes (CTLs). We used TALL-104 human leukemic CTLs as
a model. Our results confirm an earlier report (Dutz, JP, Fruman, DA, Burakoff, SJ, and
Bierer, BE (1993) J. Immunol. 150, 2591–2598) that immunosuppressive drugs inhibit
exocytosis in CTLs stimulated either via the T cell receptor (TCR) or via TCR-independent …