Species‐specific impact of the autophagy machinery on Chikungunya virus infection
EMBO reports, 2013•embopress.org
Chikungunya virus (CHIKV) is a recently re‐emerged arbovirus that triggers autophagy.
Here, we show that CHIKV interacts with components of the autophagy machinery during its
replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells
from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By
contrast, the human autophagy receptor NDP52—but not its mouse orthologue—interacts
with the non‐structural protein nsP2, thereby promoting viral replication. These results …
Here, we show that CHIKV interacts with components of the autophagy machinery during its
replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells
from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By
contrast, the human autophagy receptor NDP52—but not its mouse orthologue—interacts
with the non‐structural protein nsP2, thereby promoting viral replication. These results …
Chikungunya virus (CHIKV) is a recently re‐emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52—but not its mouse orthologue—interacts with the non‐structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity.
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