[HTML][HTML] Comparative analysis of the genome sequences and replication profiles of chikungunya virus isolates within the East, Central and South African (ECSA) …
KC Chen, YW Kam, RPT Lin, MML Ng, LFP Ng… - Virology journal, 2013 - Springer
KC Chen, YW Kam, RPT Lin, MML Ng, LFP Ng, JHJ Chu
Virology journal, 2013•SpringerBackground A comparative analysis of the genomic and replication profiles of different
geographical chikungunya virus (CHIKV) isolates of the East, Central and South African
(ECSA) lineage was performed. Findings Analysis of the data revealed the different growth
kinetics for the different isolates. Deep genome sequencing analysis further revealed
specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 and E2 proteins in the
different isolates. Despite the difference in viral genomic profiles, the virus-induced …
geographical chikungunya virus (CHIKV) isolates of the East, Central and South African
(ECSA) lineage was performed. Findings Analysis of the data revealed the different growth
kinetics for the different isolates. Deep genome sequencing analysis further revealed
specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 and E2 proteins in the
different isolates. Despite the difference in viral genomic profiles, the virus-induced …
Background
A comparative analysis of the genomic and replication profiles of different geographical chikungunya virus (CHIKV) isolates of the East, Central and South African (ECSA) lineage was performed.
Findings
Analysis of the data revealed the different growth kinetics for the different isolates. Deep genome sequencing analysis further revealed specific amino acid mutations in the viral nsP1, nsP3, nsP4, E1 and E2 proteins in the different isolates. Despite the difference in viral genomic profiles, the virus-induced ultrastructural changes within infected cells remained highly conserved among the different chikungunya virus isolates.
Conclusions
These findings provide insights into the genomic and replication profiles of the re-emerging chikungunya virus isolates of the ECSA lineage.
Springer