Deficiency of merosin in dystrophic dy mice and genetic linkage of laminin M chain gene to dy locus.

Y Sunada, SM Bernier, CA Kozak, Y Yamada… - Journal of Biological …, 1994 - ASBMB
Merosin is the predominant laminin isoform in the basal lamina of striated muscle and
peripheral nerve, and consists of M, B1 or S, and B2 chains. Here we have demonstrated
that merosin is a native ligand for alpha-dystroglycan, an extracellular component of the
dystrophin-glycoprotein complex. We have also mapped the mouse M chain gene, Lamm, to
the same region of mouse chromosome 10 to which the dystrophia muscularis (dy) locus
has been mapped. The dy mutation represents a severe neuromuscular disease resembling …