Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology
Blood, The Journal of the American Society of Hematology, 2016•ashpublications.org
Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic
anemia, episodic vaso-occlusion, and progressive organ damage. Current management of
the disease remains symptomatic or preventative. Specific treatment targeting major
complications such as vaso-occlusion is still lacking. Recent studies have identified various
cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we
review the role of these elements and discuss the opportunities for therapeutic intervention.
anemia, episodic vaso-occlusion, and progressive organ damage. Current management of
the disease remains symptomatic or preventative. Specific treatment targeting major
complications such as vaso-occlusion is still lacking. Recent studies have identified various
cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we
review the role of these elements and discuss the opportunities for therapeutic intervention.
Abstract
Sickle cell disease (SCD) is a severe genetic blood disorder characterized by hemolytic anemia, episodic vaso-occlusion, and progressive organ damage. Current management of the disease remains symptomatic or preventative. Specific treatment targeting major complications such as vaso-occlusion is still lacking. Recent studies have identified various cellular and molecular factors that contribute to the pathophysiology of SCD. Here, we review the role of these elements and discuss the opportunities for therapeutic intervention.
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